Pitt-Hopkins Syndrome Awareness Day, also known as Pitt-Hopkins Awareness Day, is observed worldwide every September 18. Established in 2013, the day aims to educate medical professionals and the general public about Pitt-Hopkins syndrome, a rare neurodevelopmental disorder caused by a mutation or deletion of the TCF4 gene on chromosome 18. The syndrome is characterized by distinctive facial features, developmental delay, and intellectual disability, affecting approximately 1,500 individuals globally. Activities on this day include supporting affected families, raising funds for research, and promoting understanding of the disorder through social media and community events. The observance highlights the need for better treatments and ultimately a cure for this condition.