Wolfram Syndrome Global Awareness Day is observed worldwide every October 1. Launched by Wolfram Syndrome UK, the day aims to highlight the ultra-rare genetic disorder known as Wolfram syndrome, which leads to diabetes, optic atrophy, and deafness. The disorder is caused by mutations in the WFS1 or CISD2 genes and is also referred to by the acronym DIDMOAD, representing its main symptoms: diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. Organizations supporting this initiative include Alianza de Familias Afectadas por el Síndrome de Wolfram (Spain), Association Syndrome de Wolfram (France), and the Snow Foundation for Wolfram Syndrome Research, among others. Activities on this day encourage individuals to learn about Wolfram syndrome, share information, donate to relevant organizations, and promote awareness through social media. The observance emphasizes the importance of early diagnosis and ongoing research into treatment methods for this incurable condition.