World Cholangiocarcinoma Day is observed worldwide every February 12 to increase awareness of cholangiocarcinoma, a rare and aggressive form of bile duct cancer. This day highlights the rising incidence of the disease, particularly in Asia, where liver flukes contribute to its prevalence. The cancer is characterized by malignant tumors in the bile ducts, which can lead to symptoms such as jaundice, abdominal pain, and weight loss. Due to the difficulty in diagnosing cholangiocarcinoma, many patients seek medical help only when the disease is advanced and inoperable. The day aims to emphasize the importance of early diagnosis and research into alternative therapies to improve patient outcomes.