MAND Awareness Day is observed worldwide every February 23 to raise awareness about MBD5-associated neurodevelopmental disorder (MAND), a genetic condition that affects neurological and physical development. This day highlights the impact of mutations in the MBD5 gene, which can lead to developmental delays, intellectual disabilities, and various physical characteristics such as distinctive facial features and skeletal abnormalities. Individuals with MAND often experience weak muscle tone, feeding problems, and sleep disturbances, and many develop epilepsy by age two. The observance aims to provide support for those affected and their families, as well as to promote research into this rare disorder. MAND Awareness Day is significant as it coincides with the genetic changes often associated with the disorder, specifically in the region of chromosome 2 known as 2q23.1.