International CVS Awareness Day is observed worldwide every March 5 to highlight cyclic vomiting syndrome (CVS), a chronic condition characterized by recurrent episodes of severe vomiting. Established in 2015 by the Cyclic Vomiting Syndrome Association (CVSA), the day aims to increase public knowledge about CVS and emphasize the need for research into its diagnosis and treatment. Participants often engage in activities such as lighting up iconic landmarks in blue, the awareness color for CVS, as part of the #LightUpCVSAwareness campaign. Individuals are encouraged to wear blue shirts or awareness ribbons, share information on social media using specific hashtags, and support organizations that aid CVS patients or fund research. CVS predominantly affects children and is thought to be linked to a family history of migraines. The observance calls upon affected individuals, healthcare professionals, and policymakers to advocate for better access to diagnosis and treatment.