Potocki-Lupski Syndrome Awareness Day is observed worldwide every March 8 to promote understanding of Potocki-Lupski syndrome (PTLS), a rare genetic condition caused by an extra copy of a portion of chromosome 17. This day was established to advocate for research and support families affected by PTLS, which is characterized by intellectual disability, autism spectrum disorder in 80% of cases, and various other symptoms. The syndrome was first described in 1996, with significant studies published by 2007, named after geneticists Drs. Lorraine Potocki and James R. Lupski. Early symptoms include feeding difficulties and low muscle tone, while distinctive physical features may also be present. There is no cure for PTLS, and treatment focuses on managing symptoms through therapies and medical interventions.