Cat Eye Syndrome Awareness Day, also known as CES Awareness Day, is observed worldwide every March 22. This day aims to educate the public about cat eye syndrome, a rare genetic condition caused by an abnormal extra chromosome that includes genetic material from chromosome 22. The syndrome is characterized by various symptoms, including vertical iris coloboma, anal abnormalities, ear anomalies, congenital heart defects, and intellectual disabilities. The day encourages participation through learning more about the condition, donating to organizations that support patients or fund research, and sharing information on social media using hashtags like #CESAwarenessDay. The observance highlights the importance of improving access to medical care and further research on this genetic disorder.