World Lipodystrophy Day is observed worldwide every March 31. Established in 2013 by the International Association of Families and People Affected by Lipodystrophies (AELIP), this day aims to highlight the challenges faced by individuals affected by lipodystrophy, a rare disorder that impacts the body's adipose tissue. People with this condition often struggle with weight management and metabolic health due to low levels of leptin, a hormone that regulates hunger and body weight. Symptoms can lead to serious health issues, including insulin resistance and metabolic syndrome. Treatment varies based on the type of lipodystrophy and may involve medications or cosmetic surgery to address the physical effects of the disorder. The observance serves to educate the public about the complexities of living with lipodystrophy and the importance of support for those affected.