National Clean Out Your Medicine Cabinet Day is observed in the USA every third Friday of April. This day encourages individuals to properly dispose of unused and expired medications, addressing the issue that approximately one-third of the six billion prescriptions filled annually in the U.S. go unused. Launched in 2019 by DisposeRx, a North Carolina-based company, the day aims to educate the public about the risks associated with keeping leftover medications at home and the importance of safe disposal methods. People are encouraged to participate in various disposal options, including the U.S. Drug Enforcement Administration's National Take Back Days, which occur twice a year, and local drug take-back events. Safe disposal methods include using registered pharmacies or healthcare facilities, mail-back envelopes, or at-home disposal kits. If these options are unavailable, individuals can mix medications with unappealing substances and dispose of them in the trash.