PPA2 Awareness Day is observed worldwide every May 2 to promote understanding of inorganic pyrophosphatase 2 (PPA2) deficiency, a rare genetic disorder that can lead to sudden cardiac death. Established in 2025, the day is organized by Heart of PPA2, a nonprofit organization dedicated to advocating for research and supporting patients and their families affected by this condition. PPA2 deficiency results from mutations in the PPA2 gene, leading to symptoms such as neurological issues, muscle weakness, and cardiomyopathy. The event encourages individuals to learn about the disorder, share information, donate to the organization, and utilize the hashtag #PPA2AwarenessDay on social media to spread awareness. The day serves as a platform to connect those impacted by PPA2 deficiency, emphasizing the importance of community and support in managing this serious health issue.