REDS4VEDS Day is observed worldwide on the third Friday of May and serves as an annual awareness campaign for vascular Ehlers-Danlos syndrome (vascular EDS), a rare genetic connective tissue disorder. The day was co-founded by Jared Griffin and Evie Evans to educate the public about vascular EDS and to support affected families and research. It is hosted by the UK charity Annabelle’s Challenge, which was established by the Griffins after their daughter was diagnosed with the condition. Participants are encouraged to donate or organize fundraisers for the global REDS4VEDS campaign. Additionally, individuals can show their support by wearing red, taking selfies, and sharing them on social media with the hashtag #REDS4VEDS. The day highlights the challenges faced by patients, including the risk of spontaneous blood vessel rupture and the need for careful management of the condition.