NF2 Awareness Day is observed worldwide every May 22 to promote understanding of neurofibromatosis type II (NF2), a rare genetic disorder characterized by benign tumors in the nervous system. This day was established to highlight NF2, which is less common than other types of neurofibromatosis, and to encourage research into new treatments, including gene therapy. NF2 is caused by a mutation on chromosome 22 affecting the gene that encodes the tumor suppressor protein merlin, leading to the development of tumors, particularly on the auditory vestibular nerve. Symptoms typically manifest in adolescence or early adulthood and can include tinnitus, hearing loss, and balance issues. There is currently no cure for NF2, and treatment often involves surgical intervention and assistive technologies. The observance of NF2 Awareness Day follows Neurofibromatosis Awareness Day, which is dedicated to all types of neurofibromatosis, emphasizing the need for focused attention on this specific condition.