KGB Syndrome Awareness Day is observed worldwide every June 11 to promote understanding of KGB syndrome, an ultra-rare genetic condition caused by a mutation in the ANKRD11 gene. This syndrome affects multiple organs and systems, leading to symptoms such as distinctive facial features, congenital heart defects, and developmental delays. The day was established by the KGB Syndrome Foundation, which supports affected families and advances research on the condition. The inaugural observance took place in 2016, and the date has changed over the years to avoid conflicts with other significant dates. The number 11 in the date references the ANKRD11 gene. Despite the challenges posed by KGB syndrome, many individuals can lead fulfilling lives with appropriate care and support.