Maple Syrup Urine Disease Awareness Day, also known as MSUD Awareness Day, is observed worldwide every June 16. This day was created to highlight maple syrup urine disease (MSUD), a rare genetic disorder that affects amino acid metabolism due to mutations in specific genes. The condition leads to a buildup of branched-chain amino acids (BCAAs) in the body, causing urine and earwax to smell like maple syrup, along with various neurological symptoms. There are five main types of MSUD, with classic MSUD being the most common, presenting symptoms within the first 24 to 48 hours of life. Management of MSUD includes dietary restrictions and medical treatments to lower BCAA levels. The observance aims to support affected patients and advocate for research into therapies and potential cures.