GIST Awareness Day is observed worldwide every July 13 to promote understanding of gastrointestinal stromal tumors (GISTs), a rare type of soft-tissue sarcoma that primarily originates in the gastrointestinal tract. The day was established by the Lift Raft Group (LRG), a nonprofit organization that supports GIST patients, following the success of their Rare 13 campaign in 2013, which highlighted that approximately 13 individuals in the U.S. are diagnosed with GIST daily. The first GIST Awareness Day was organized in 2014, and since then, it has aimed to ensure that patients have access to essential support and resources while advocating for ongoing research to enhance diagnosis, treatment, and patient outcomes. Symptoms of GIST can be nonspecific and include abdominal pain, nausea, and weight loss, making early diagnosis challenging. The observance encourages public engagement with the condition and emphasizes the importance of awareness in improving patient care.