Barth Syndrome Awareness Day is observed worldwide every April 5 to spread information about Barth syndrome, an ultra-rare and potentially life-threatening disorder primarily affecting males due to a mutation in the TAFAZZIN gene. The day was established to unite individuals affected by the condition, their families, medical professionals, and advocates to promote research and improve access to diagnosis and treatment. Symptoms of Barth syndrome can include dilated cardiomyopathy, muscle weakness, and delayed growth, among others. The syndrome is estimated to occur in one in 300,000 to 400,000 births, but it is believed to be underdiagnosed. There is currently no specific cure, although ongoing research, such as the clinical development of elametride, aims to address the condition. Participants are encouraged to learn more about Barth syndrome, support the Barth Syndrome Foundation, and share information using the hashtag #BarthSyndromeAwareness.