International Angelman Day is observed worldwide every February 15 to raise awareness of Angelman syndrome (AS), a rare genetic disorder primarily affecting the nervous system. The day was launched in 2013 by two parents of children with AS, coinciding with International Rare Disease Month and referencing the affected 15th chromosome. Typical symptoms of AS include severe developmental delay, speech impairment, ataxia, and an unusually happy demeanor. Organizations such as the Angelman Syndrome Foundation and the Foundation for Angelman Syndrome Therapeutics (FAST) support events that promote awareness, research, and support for individuals with AS and their families. Observers can participate by learning about the syndrome, donating to relevant organizations, and sharing their experiences on social media using the hashtags #InternationalAngelmanDay and #WhatIsAngelman.