World Cholangiocarcinoma Day is observed on the third Thursday in February to raise awareness about cholangiocarcinoma, a rare and aggressive type of cancer that affects the bile ducts and gallbladder. This day brings together doctors, healthcare workers, cancer survivors, and activists to highlight the importance of understanding this deadly disease, which is difficult to diagnose and often presents no symptoms. In the United States, approximately 11,000 cases are diagnosed annually, making it one of the rarest and most lethal forms of cancer. The lack of specific screening tests complicates early detection, as tumors are usually discovered during tests for other conditions. Observers are encouraged to promote healthy liver habits and support those battling cancer. The day serves as a reminder of the need for increased research and awareness surrounding cholangiocarcinoma.