International Alagille Syndrome Awareness Day is observed worldwide every January 24, in honor of the birthday of French pediatric hepatologist Daniel Alagille, who first described the condition in 1969. This day aims to promote understanding of Alagille syndrome (ALGS), a rare genetic disorder characterized by narrow and malformed bile ducts, which can lead to liver damage and affect other organs. The syndrome is caused by mutations in the JAG1 or NOTCH2 genes, impacting the Notch signaling pathway crucial for embryonic development. Individuals and organizations participate by learning about ALGS, donating to support research and patient care, and using the hashtag #ALGSAwarenessDay on social media to spread information about the disorder. Although there is no cure, management strategies include medications, skincare products, vitamin supplements, and, in severe cases, surgery or liver transplants. The prevalence of ALGS is estimated to be between 1 in 30,000 and 1 in 100,000 live births, with symptoms that can vary greatly in severity.