AMKD Awareness Day is observed worldwide every last Tuesday of April. Established by the American Kidney Fund, this day aims to educate the public about APOL1-mediated kidney disease (AMKD), which is linked to mutations in the apolipoprotein L1 (APOL1) gene. These mutations, common among individuals of West and Central African descent, can increase the risk of kidney disease, with about 20% of those with two copies of the risk variant likely to develop AMKD. The day encourages people, particularly those with African ancestry, to get their kidneys checked and consider genetic testing, especially if there is a family history of kidney disease. Activities typically include educational campaigns and outreach efforts focused on kidney health, symptom management, and lifestyle changes to prevent disease progression.