TUBB3 Variant Awareness Day, also known as TUBB3 Awareness Day, is observed worldwide every March 16. This day was established to highlight the syndromes caused by mutations in the TUBB3 gene, which is crucial for the development and function of nerve cells. Mutations in this gene can lead to TUBB3-related tubulinopathy, a rare genetic disorder with symptoms that include eye movement disorders, low muscle tone, developmental delays, and seizures. The observance aims to advocate for research into this ultra-rare disorder and provide support for affected individuals and families. People participate by learning about TUBB3-related disorders, sharing information on social media using the hashtag #TUBB3, and supporting the TUBB3 Foundation through donations or merchandise purchases. The date, March 16, corresponds to the location of the TUBB3 gene on the 16th chromosome.