National Adverse Drug Event Awareness Day is observed annually on March 24 in the United States. The day aims to raise awareness about adverse drug events (A.D.E.s), which occur when individuals are harmed or negatively affected by medications. A.D.E.s account for significant healthcare impacts, including 3.5 million doctor visits and 2.2 million hospital admissions each year, costing the U.S. healthcare system approximately $136 billion. The American Society of Pharmacovigilance established this observance to highlight the importance of reporting A.D.E.s, which include allergic reactions, medication errors, and overdoses. It is encouraged that individuals report any adverse reactions to the FDA's MedWatch program, as less than 10% of these events are currently reported. This initiative emphasizes the need for increased awareness and education regarding the safe use of medications.