International Huntington’s Disease Awareness Day is observed worldwide every year on May 15. This day aims to highlight Huntington's disease (HD), a rare genetic disorder characterized by the progressive degeneration of neurons in the brain, leading to symptoms similar to amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease. The disorder was first described in the Middle Ages and recognized as a distinct condition in the late 19th century, named after American physician George Huntington, who published its first thorough description in 1872. Organizations such as the Huntington’s Disease Society of America, Huntington Society of Canada, and the European Huntington Association play a significant role in promoting awareness and education about the disease. The observance emphasizes the importance of genetic testing and available treatments that can help manage HD symptoms and improve the quality of life for patients.