HoFH Awareness Day is observed worldwide every May 4 to highlight homozygous familial hypercholesterolemia (HoFH), a genetic disorder that leads to high cholesterol levels and cardiovascular disease, particularly in children. The day was established by the FH Europe Foundation to emphasize the importance of proper diagnosis and treatment for this rare condition, which affects approximately one in 250,000 to 360,000 people, with higher prevalence in certain populations due to the founder effect. Activities on this day include educating the public about HoFH, sharing information on social media using the hashtag #HoFHAwarenessDay, and encouraging donations to organizations that support HoFH patients and research. The date was chosen for its phonetic resemblance to the phrase "May the Force be with you," linking it to Star Wars Day and symbolizing the strength and resilience needed to face health challenges.