Emanuel Syndrome Awareness Day is observed worldwide every November 22 to raise global awareness of Emanuel syndrome, a rare genetic disorder caused by an unbalanced translocation between chromosomes 11 and 22. This condition results in multiple congenital abnormalities, including characteristic facial features such as a prominent forehead, widely spaced eyes, and a small jaw. Individuals with Emanuel syndrome often experience developmental delays, intellectual disabilities, and various health issues, requiring a multidisciplinary approach for treatment and care. The date of November 22 was chosen because it corresponds to the affected chromosomes, 11 and 22. The day aims to provide support to families impacted by this disorder and to promote understanding of its complexities.