International Gaucher Day is observed worldwide every October 1 to educate the public about Gaucher disease, a rare genetic disorder that affects multiple organs. Established in 2014 by the European Gaucher Alliance, now known as the International Gaucher Alliance, the day aims to support patients and their families while improving early diagnosis and treatment options. Gaucher disease is classified into three types, with varying symptoms and prognoses, and is characterized by a deficiency of the enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside in organs such as the spleen, liver, and bone marrow. The observance highlights the importance of understanding the disease, which is particularly prevalent among Ashkenazi Jews, and encourages discussions about treatment options like enzyme replacement therapy and substrate reduction therapy.