PFIC Awareness Day is observed worldwide every October 5 to educate the public about progressive familial intrahepatic cholestasis (PFIC), a group of genetic disorders that impair bile flow from the liver to the duodenum. The day aims to support affected families and raise funds for further research into this rare disease, which is characterized by symptoms such as itching, jaundice, and deficiencies of fat-soluble vitamins. Launched in 2019, PFIC Awareness Day encourages individuals to learn about PFIC, share information, and donate to organizations that assist patients or fund research. The condition is caused by mutations in specific genes, leading to defective transport proteins essential for bile formation and secretion. Diagnostic tests for PFIC include liver function tests, liver biopsies, and genetic testing, although many patients remain undiagnosed due to the unavailability of genetic testing. Treatment is primarily supportive, with some patients requiring liver transplants as the disease progresses.