MPN Awareness Day is observed worldwide every second Thursday of September to highlight myeloproliferative neoplasms (MPNs), a group of rare blood cancers characterized by the excessive production of blood cells in the bone marrow. The day aims to encourage individuals living with MPNs to share their experiences, offer hope to newly diagnosed patients, and connect the global MPN community. Activities include learning about MPNs, donating to organizations that support patients and research, and using the hashtag #MPNAwarenessDay on social media to spread information. MPNs are chronic conditions that primarily affect older adults and can lead to serious complications, making awareness and support crucial for improving patient quality of life.