Lissencephaly Awareness Day is observed worldwide every September 8 to promote understanding of lissencephaly, a rare brain disorder characterized by a lack of folds and grooves on the brain's surface, leading to developmental delays and cognitive impairment. The day was established to highlight the challenges faced by individuals with this condition, which can result from factors such as viral infections during pregnancy, insufficient blood supply to the brain, or genetic mutations. The Lissencephaly Foundation, a nonprofit organization based in the U.S., plays a key role in supporting families affected by this disorder. Activities on this day include educating others about lissencephaly, donating to the foundation, and sharing information on social media using the hashtag #LissencephalyAwarenessDay. Although there is no cure, some children can make developmental progress with appropriate care and therapy. Life expectancy for those with lissencephaly is typically short, with many not living past ten years.