Smith-Kingsmore Syndrome Awareness Day is observed worldwide every August 15. Established to highlight Smith-Kingsmore syndrome (SKS), an ultra-rare genetic disorder caused by mutations in the MTOR gene, the day aims to support families affected by the condition and promote further research. SKS is characterized by various symptoms, including distinctive physical features such as macrocephaly and a triangular face, as well as neurological issues like intellectual disability and seizures. The awareness day has been recognized since 2020 and encourages education about the disorder and its impact on individuals and families. Treatment plans for SKS are tailored to each patient’s specific symptoms and may involve a multidisciplinary team of healthcare professionals.