World Eosinophilic Esophagitis Day, also known as World EoE Day, is observed worldwide every May 22. Established by EoE patient organizations from various countries in 2025, it aims to educate the public about eosinophilic esophagitis (EoE), a chronic allergic inflammatory condition affecting the esophagus. EoE is characterized by an abnormal accumulation of eosinophils, a type of white blood cell, in the esophagus, leading to inflammation and tissue damage when certain trigger foods are consumed. The day focuses on informing healthcare professionals and the general public about EoE symptoms, which can vary by age, and encourages individuals experiencing persistent acid reflux or difficulty swallowing to seek medical advice. The campaign advocates for better care, access to treatment, and further research into EoE, particularly in low- and middle-income countries.