International SGS Awareness Day, also known as International Schinzel-Giedion Syndrome Awareness Day, is observed worldwide every November 13. This day was established by the Schinzel-Giedion Syndrome Foundation, a UK charity founded on November 13, 2019, to celebrate its anniversary and support families affected by this rare genetic neurodegenerative disorder. Schinzel-Giedion syndrome (SGS) is caused by a gain-of-function mutation of the SETBP1 gene, leading to severe neurodevelopmental delays and various health complications. On this day, individuals are encouraged to learn about SGS, share information, donate to relevant organizations, and promote awareness through social media. The day aims to highlight the challenges faced by those impacted by the syndrome and foster a supportive community.